sLORETA in Clinical Practice

Not All ROIs Are Created Equal

Authored by: Mark Llewellyn Smith

Handbook of Clinical QEEG and Neurotherapy

Print publication date:  November  2016
Online publication date:  November  2016

Print ISBN: 9781138802643
eBook ISBN: 9781315754093
Adobe ISBN: 9781317623083


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QEEG driven neurofeedback relies on a statistical threshold of significance to define pathology. Many, if not most, clinicians would describe abnormal brain electrical activity as two standard deviations from the mean value being assessed. This threshold is not always achieved in networks of function in a clinical setting. When this occurs it becomes necessary to analyze brain structures most often related to pathological behavior with a lower statistical threshold. Clinical experience with sLORETA/LORETA training has led to the establishment of a hierarchical set of regions of interest (ROI) that most often lead to clinical success.

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