Bovine Spongiform Encephalopathy

Authored by: Akikazu Sakudo , Takashi Onodera

Molecular Detection of Animal Viral Pathogens

Print publication date:  August  2016
Online publication date:  May  2016

Print ISBN: 9781498700368
eBook ISBN: 9781498700375
Adobe ISBN:


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Prion diseases, or transmissible spongiform encephalopathies (TSEs), are fatal neurological diseases that include Creutzfeldt-Jakob disease (CJD) in humans, scrapie in sheep and goats, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in cervids, transmissible mink enceph-alopathy in minks, feline spongiform encephalopathy in cats, and exotic ungulate encephalopathy in zoo animals such as the kudu, nyala, gemsbok, eland, and oryx. The prion agent of each disease is named after the disease itself (e.g., CJD agent in CJD, scrapie agent in scrapie). A key event in the development of prion diseases is the conversion of the cellular, host-encoded prion protein (PrPC) to its abnormal isoform (PrPSc) predominantly in the central nervous system (CNS) of the infected host [1]. This chapter will introduce the molecular detection of BSE as well as the fundamental aspects of the disease.

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