Iflavirus (Deformed Wing Virus)

Authored by: Jessica M. Fannon , Eugene V. Ryabov

Molecular Detection of Animal Viral Pathogens

Print publication date:  August  2016
Online publication date:  May  2016

Print ISBN: 9781498700368
eBook ISBN: 9781498700375
Adobe ISBN:


 Download Chapter



The genus Iflavirus includes diverse RNA viruses of arthropods, which have icosahedral nonenveloped virus particles about 26-32 nm in diameter (Figure 5.1a). Iflavirus virions contain a single copy of linear positive-sense 8-10 kb genomic RNA that possesses small genome-linked virus protein, Vpg, covalently linked to the 5′ terminus and poly(A) sequence at the 3′ terminus. Genomic RNAs of iflaviruses have extended 5′ untranslated region (5′UTR), reaching about 1 kb, which acts as an internal ribosome entry signal (IRES). The IRES is followed by a single open reading frame (ORF) coding for a large polyprotein, ranging in size from 2800 to 3200 amino acids (aa), with the structural proteins and the nonstructural proteins encoded by the 5′- and 3′-parts of the ORF, respectively (Figure 5.1) [1]. Iflavirus genomic RNA is infectious and serves as a template for the synthesis of viral polyprotein. The genus name is derived from the name of its type species, infectious flacherie virus, a pathogen of the silkworm Bombyx mori [2].

Search for more...
Back to top

Use of cookies on this website

We are using cookies to provide statistics that help us give you the best experience of our site. You can find out more in our Privacy Policy. By continuing to use the site you are agreeing to our use of cookies.