Iflavirus (Deformed Wing Virus)

Authored by: Jessica M. Fannon , Eugene V. Ryabov

Molecular Detection of Animal Viral Pathogens

Print publication date:  August  2016
Online publication date:  May  2016

Print ISBN: 9781498700368
eBook ISBN: 9781498700375
Adobe ISBN:

10.1201/b19719-ch5

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Abstract

The genus Iflavirus includes diverse RNA viruses of arthropods, which have icosahedral nonenveloped virus particles about 26-32 nm in diameter (Figure 5.1a). Iflavirus virions contain a single copy of linear positive-sense 8-10 kb genomic RNA that possesses small genome-linked virus protein, Vpg, covalently linked to the 5′ terminus and poly(A) sequence at the 3′ terminus. Genomic RNAs of iflaviruses have extended 5′ untranslated region (5′UTR), reaching about 1 kb, which acts as an internal ribosome entry signal (IRES). The IRES is followed by a single open reading frame (ORF) coding for a large polyprotein, ranging in size from 2800 to 3200 amino acids (aa), with the structural proteins and the nonstructural proteins encoded by the 5′- and 3′-parts of the ORF, respectively (Figure 5.1) [1]. Iflavirus genomic RNA is infectious and serves as a template for the synthesis of viral polyprotein. The genus name is derived from the name of its type species, infectious flacherie virus, a pathogen of the silkworm Bombyx mori [2].

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