Feline Leukemia Virus

Authored by: Dongyou Liu

Molecular Detection of Animal Viral Pathogens

Print publication date:  August  2016
Online publication date:  May  2016

Print ISBN: 9781498700368
eBook ISBN: 9781498700375
Adobe ISBN:

10.1201/b19719-ch22

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Abstract

Feline leukemia virus (FeLV) is a single-stranded, positive-sense RNA of the family Retroviridae that is associated with proliferative, degenerative, and malignant diseases of myeloid, erythroid, and lymphoid origins in cats worldwide. Despite having a relatively simple genome, FeLV is capable of producing variants of enhanced pathogenic potential through genetic recombinations with endogenous FeLV (enFeLV)-related sequences in the feline genome. By suppressing the host immune system and predisposing cats to secondary infections, FeLV is responsible for up to 85% of mortality in persistently infected felines within 3 years of diagnosis.

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