Authored by: Mohammad Reza Ay , Nafiseh Ghazanfari

Handbook of Small Animal Imaging

Print publication date:  April  2016
Online publication date:  February  2016

Print ISBN: 9781466555686
eBook ISBN: 9781466555693
Adobe ISBN:


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The advent of dual-modality PET/CT imaging has revolutionized the practice of clinical and pre-clinical studies by improving lesion localization and the possibility of accurate quantitative analysis. In addition, the use of CT images for CT-based attenuation correction (CTAC) of PET data allows to decrease the overall scanning time and to create a noise-free attenuation map. The near simultaneous data acquisition in a fixed combination of a PET and a CT scanner in a hybrid PET/CT imaging system with a common table minimizes spatial and temporal mismatches between the modalities by eliminating the need to move the object in between exams. The purpose of this chapter is to introduce the principles of PET/CT imaging systems and describe the sources of error and artifact in CTAC algorithm. This chapter also focuses on currently available PET/CT systems and their areas of application. It should be noted that due to limited space the references contained herein are for illustrative purposes and are not inclusive, and not to imply that those chosen are better than others that are not mentioned.

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