TRPC channels

Authored by: Jin-Bin Tian , Dhananjay Thakur , Yungang Lu , Michael X. Zhu

Handbook of Ion Channels

Print publication date:  February  2015
Online publication date:  February  2015

Print ISBN: 9781466551404
eBook ISBN: 9781466551428
Adobe ISBN:

10.1201/b18027-31

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Abstract

The canonical subfamily of transient receptor potential (TRPC) channels was identified based on their sequence homology to the prototypical Drosophila TRP protein (Zhu et al., 1996; Montell et al., 2002), which when mutated caused a transient receptor potential (trp) phenotype, impairing phototransduction of the fruit fly (Cosens and Manning, 1969). Among the 28 TRP channels found in mammals, the 7 TRPC members have the closest homology with the Drosophila TRP. However, their functions are typically not associated with mammalian phototransduction. In fact, TRPC channels have been shown to play roles in many body systems. While early studies have concentrated on evaluating the contribution of TRPC channels in store-operated Ca2+ entry commonly present in nearly all cells, more recent investigations have focused on elucidating physiological functions of individual TRPC channels in different systems and cell types, resulting from not only Ca2+ but also Na+ influx mediated by the opened TRPC channels. This chapter will begin with an overview of the biophysical and pharmacological responses of, primarily, heterologously expressed TRPC channels and then provide a succinct discussion about main physiological functions of native TRPC channels, focusing mainly on the nervous system.

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