Cyclic nucleotide–gated channels

Authored by: D. Varnum Michael , Dai Gucan

Handbook of Ion Channels

Print publication date:  February  2015
Online publication date:  February  2015

Print ISBN: 9781466551404
eBook ISBN: 9781466551428
Adobe ISBN:

10.1201/b18027-28

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Abstract

Ion channels that are activated by the direct binding of intracellular cyclic nucleotides are best known for the essential role they play in sensory transduction, including vision and olfaction. In these sensory cells, they transduce a chemical signal produced by the stimulus input—a change in the intracellular concentration of guanosine 3′,5′-cyclic monophosphate (cGMP) or adenosine 3′,5′-cyclic monophosphates (cAMP)—into an electrical response via a change in cation conductance through the channel pore. Cyclic nucleotide–gated (CNG) channels are tetrameric complexes of homologous subunits, with each subunit contributing a cyclic nucleotide–binding domain (CNBD), part of the ion conduction pathway, and the fundamental machinery to covert cGMP or cAMP binding into channel opening. Here, we review their functional and structural properties and their physiological and pathophysiological roles.

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