Crimean-Congo Hemorrhagic Fever Virus

Authored by: Ayse Erbay

Manual of Security Sensitive Microbes and Toxins

Print publication date:  April  2014
Online publication date:  April  2014

Print ISBN: 9781466553965
eBook ISBN: 9781466553989
Adobe ISBN:


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Crimean-Congo hemorrhagic fever (CCHF) virus is the most extensive tick-borne virus causing a fatal viral infection in humans. CCHF has been known for a long time in Central Asia; a case reported of a hemorrhagic syndrome from where Tajikistan is in present day in the twelfth century may have been the first known case of CCHF [1,2]. In 1944, an acute febrile illness, accompanied with severe bleeding in over 200 Soviet military personnel who were bitten by ticks, in the Steppe region of western Crimea was first described as Crimean hemorrhagic fever, but the virus could not be isolated at that time. Later, it was shown that a viral strain isolated from a patient suffering from Crimean hemorrhagic fever was antigenically identical to Congo virus that was isolated from a febrile patient in Democratic Republic of Congo in 1956 and the combined name Crimean-Congo hemorrhagic fever virus (CCHFV) has been used since the late 1970s [1,3].

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