Cercopithecine herpesvirus 1 (B Virus)

Authored by: Dongyou Liu

Manual of Security Sensitive Microbes and Toxins

Print publication date:  April  2014
Online publication date:  April  2014

Print ISBN: 9781466553965
eBook ISBN: 9781466553989
Adobe ISBN:


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Cercopithecine herpesvirus 1 (CeHV-1), also known as Herpesvirus simiae, monkey B virus, herpesvirus B, herpes B virus, or simply B virus, was first identified from a human patient in 1932. The patient, a young physician named William Brebner, became infected after being bitten by a monkey during research on poliomyelitis-causing virus, with symptoms ranging from localized erythema, lymphangitis, lymphadenitis, to transverse myelitis. Following his death, an ultrafilterable agent showing similarity to herpes simplex virus (HSV) in cell culture was isolated from neurologic tissues of the patient and was initially named “W virus,” and subsequently “B virus” [1]. By 2011, about 50 human cases of B virus infections had been documented, with a high proportion of these patients succumbing to the disease in a relatively short period after acquiring the virus.

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