Coccidioides ( C. posadasii and C. immitis )

Authored by: Rossana de Aguiar Cordeiro , Marcos Fábio Gadelha Rocha , Raimunda Sâmia Nogueira Brilhante , José Júlio Costa Sidrim

Manual of Security Sensitive Microbes and Toxins

Print publication date:  April  2014
Online publication date:  April  2014

Print ISBN: 9781466553965
eBook ISBN: 9781466553989
Adobe ISBN:

10.1201/b16752-41

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Abstract

Coccidioides spp. are dimorphic fungi that cause coccidioidomycosis, a deep-seated infection that occurs in humans and several mammal species. The disease is caused by two nearly identical species, Coccidioides immitis and Coccidioides posadasii, which share many biological traits regarding immunogenicity, pathogenicity, and virulence. Both species are soil-inhabiting fungi that occur in arid and semiarid areas in the Americas. Coccidioides spp. are considered the most virulent fungal pathogens of humans and animals, 1 being classified as biosafety level 3 microorganisms by regulatory agencies around the world. Coccidioides are considered important laboratory hazard and potential bioweapons. 2

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