Tick-Borne Encephalitis Viruses

Authored by: Oliver Donoso-Mantke , Camille Escadafal , Andrea Sanchini , Cristina Domingo , Peter Hagedorn , Pranav Patel , Katharina Achazi , Antje Hüther , Matthias Niedrig

Manual of Security Sensitive Microbes and Toxins

Print publication date:  April  2014
Online publication date:  April  2014

Print ISBN: 9781466553965
eBook ISBN: 9781466553989
Adobe ISBN:


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Tick-borne encephalitis (TBE) is a life-threatening neurological infection affecting humans. 1 Tick-borne encephalitis virus (TBEV) is the etiological agent of TBE. It was discovered in 1937 in Russia during an expedition led by Lev Zilber searching for the etiological agent of acute encephalitis associated with tick bites. 1 Subsequently, three subtypes of TBEV have been identified using serological techniques: the European virus TBEV-Eu (previously Central European encephalitis [CEE] virus), the Far Eastern virus TBEV-Fe (previously Russian spring–summer encephalitis [RSSE] virus), and the Siberian virus TBEV-Sib (previously west Siberian virus). 2 Because of their pathogenic potential in humans, these TBEV subtypes were included in the HHS list of select agents and toxins by Centers for Disease Control and Prevention (CDC) of the United States. 2a In the ruling dated October 5, 2012, the European virus TBEV-Eu (CEE virus) was removed from the HHS list of select agents and toxins due to its relatively low virulence in humans in comparison with other TBEV subtypes. 2b

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