Japanese Encephalitis Virus

Authored by: Dongyou Liu

Manual of Security Sensitive Microbes and Toxins

Print publication date:  April  2014
Online publication date:  April  2014

Print ISBN: 9781466553965
eBook ISBN: 9781466553989
Adobe ISBN:


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First isolated in 1935 from a 19 year old who died of encephalitis in Tokyo, Japan, Japanese encephalitis virus (JEV) is an arthropod-borne virus (or arbovirus) that involves mosquitoes, pigs, and water birds during its life cycle. Besides causing reproductive disorder in pigs (amplifying host), JEV is also responsible for inducing encephalitis in humans (dead-end host, due to the low level and transient viremia, which is insufficient for the virus to spread to the next host through mosquito bites). Despite the availability of vaccines, JEV remains a serious public health concern in eastern and southern Asia as a result of increased population density, deforestation, and the expanding irrigation of agricultural areas. It is estimated that JEV is responsible for >50,000 cases annually, including at least 10,000 deaths and 15,000 cases with neuropsychiatric sequelae [1].

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