Laser Immunotherapy

Authored by: Tomas Hode , Xiaosong Li , Mark Naylor , Lars Hode , Peter Jenkins , Gabriela Ferrel , Robert E. Nordquist , Orn Adalsteinsson , John Lunn , Michael R. Hamblin , Luciano Alleruzzo , Wei R. Chen

Handbook Ofphotomedicine

Print publication date:  October  2013
Online publication date:  October  2013

Print ISBN: 9781439884690
eBook ISBN: 9781439884706
Adobe ISBN:

10.1201/b15582-72

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Abstract

The ultimate control of cancer lies in the host’s immune sur-veillance and defense system. Many immunotherapy strategies have been proposed to target cancer, including cytokine ther-apy, dendritic cell (DC)-based vaccines, and immune-activating antibodies, either alone or in various combinations with other therapies. However, thus far, these immunotherapy strategies have yielded low response rates, usually in the range of 5%–10% among treated patients. Novel approaches are therefore needed to increase the efficacy of immunotherapies. Ideally, such novel approaches should achieve a potent systemic, tumor-specific immunological response through a minimally invasive, local intervention to suppress local tumors and at the same time eradicate metastases at distant sites, while providing antitumor immunity to the host with minimal adverse side effects.

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