Recent Advances in Developing Improved Agents for Photodynamic Therapy

Authored by: Penny Joshi , Courtney Saenz , Joseph R. Missert , Ravindra K. Pandey

Handbook Ofphotomedicine

Print publication date:  October  2013
Online publication date:  October  2013

Print ISBN: 9781439884690
eBook ISBN: 9781439884706
Adobe ISBN:


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Photodynamic therapy (PDT) involves local activation of a drug called a photosensitizer (PS), whereby the PS accumulates in tumor tissue, and by means of light, the PS is activated. The activated PS reacts with triplet O2 to produce singlet oxygen (van Lier 1990), which a result of its cytotoxic behavior, believed to be responsible for tumor destruction (Ethirajan et al. 2011). PSs are activated by light of specific wavelengths, and the depth that light will penetrate into tissue is wavelength dependent (Gudgin Dickson, Goyan, and Pottier 2002). Thus, the combination of PS and wavelength of light for PDT is determined by the location of the tumor (National Cancer Institute, 2011.

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