Botanical Antioxidants for Photochemoprevention

Authored by: Eiman Mukhtar , Vaqar Adhami , Hasan Mukhtar

Handbook Ofphotomedicine

Print publication date:  October  2013
Online publication date:  October  2013

Print ISBN: 9781439884690
eBook ISBN: 9781439884706
Adobe ISBN:

10.1201/b15582-17

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Abstract

Exposure to ultraviolet (UV) radiation is the major cause of skin disorders, such as sunburn, photodamage, and skin cancer. Skin cancer is the most common of all cancers as the number ofbasal cell and squamous cell skin cancers (i.e., nonmelanoma skin cancers or NMSC) and its estimation has been limited because these cases are not required to be reported to cancer registries. One report on NMSC occurrence in the United States estimated that 3.5 million cases were diagnosed and 2.2 million people were treated in 2006 (Siegel, Naishadham, and Jemal 2013). It is also the easiest to cure if diagnosed and treated early; however, once allowed to progress, skin cancer can result in disfigurement morbidity and even mor-tality. Similar trends are reported from many other countries with a predominantly Caucasian population. In contrast, melanoma is the most severe form of skin cancer with an estimated 76,690 new cases in the United States in 2013, according to recent statistics (Siegel, Naishadham, and Jemal 2013). This reflects a significant rise of 6460 cases from 2011 figures. The number of melanomarelated deaths has risen as well by almost 300 cases—from 9180 deaths in 2012 to a predicted 9480 deaths in 2013.

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