Drug Interactions with Nutrients and Natural Products

Mechanisms and Clinical Importance

Authored by: David J. Greenblatt

Handbook of Nutrition and Food

Print publication date:  July  2013
Online publication date:  April  2016

Print ISBN: 9781466505711
eBook ISBN: 9781466505728
Adobe ISBN:

10.1201/b15294-78

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Abstract

The clinical problem of prescription drug interactions with nutrients and natural products is now widely recognized. Initial attention to the problem began with the first report of a pharmacokinetic drug interaction involving grapefruit juice (GFJ) and the calcium channel antagonist agent, felodipine. 1 Since this time, hundreds of publications have appeared in the medical and scientific literature describing the mechanisms and consequences of pharmacokinetic interactions between GFJ and a number of prescription medications. 2 12 There has also been extensive coverage by the lay media, much of which is sensationalized and inaccurate.

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