Phototoxicity of Drugs

Authored by: Virginie Lhiaubet-Vallet , Miguel Angel Miranda

CRC Handbook of Organic Photochemistry and Photobiology

Print publication date:  March  2012
Online publication date:  March  2012

Print ISBN: 9781439899335
eBook ISBN: 9781466561250
Adobe ISBN:

10.1201/b12252-67

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Abstract

Photosensitizing effects of xenobiotics are of increasing concern in dermatology since modern lifestyle often associates sunlight exposure with the presence of chemical substances in the skin. Photosensitization is defined by the development of abnormal cutaneous reactions triggered by sunlight doses regarded as harmless, most often in the UVA range (320–400 nm). The photosensitizing compound, generally not toxic by itself, becomes reactive under irradiation. An important number of chemicals like perfumes, sunscreen components, or therapeutic agents have been reported as photosensitizers [15].

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