Photodynamic Therapy

Authored by: Clare Conway , Stanley B. Brown

CRC Handbook of Organic Photochemistry and Photobiology

Print publication date:  March  2012
Online publication date:  March  2012

Print ISBN: 9781439899335
eBook ISBN: 9781466561250
Adobe ISBN:

10.1201/b12252-65

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Abstract

Photodynamic therapy (PDT) is a clinically approved modality that utilizes a photosensitizing compound in conjunction with light and molecular oxygen to produce a localized cytotoxic effect. The photosensitizer is nontoxic in the absence of light. PDT has gained greatest acceptance in the fields of oncology (especially oncological dermatology) and ophthalmology, although other non-oncological and antimicrobial applications have recently begun to be exploited. Specific illumination of the photosensitizer results in the local formation of reactive oxygen species, primarily singlet oxygen, causing a variety of direct and indirect cytotoxic effects on the cellular targets, discussed in more detail in Section 64.2.

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