Photoimmunology

Authored by: Vivienne E. Reeve

CRC Handbook of Organic Photochemistry and Photobiology

Print publication date:  March  2012
Online publication date:  March  2012

Print ISBN: 9781439899335
eBook ISBN: 9781466561250
Adobe ISBN:

10.1201/b12252-64

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Abstract

Photoimmunology has its origins in the landmark studies around 25 years ago that demonstrated the immunogenic nature of UV radiation–induced skin tumors taken from mice by the failure of their growth when fragments of these tumors were transplanted into naïve syngeneic recipient mice (Kripke 1974; Daynes and Spellman 1977). That the tumor rejection was immunological was shown by the reversal of the rejection by immunosuppressive drugs. Furthermore, if the recipient mice were pre-exposed to a subcarcinogenic dose of UV radiation, transplanted tumors again survived and grew, indicating for the first time that UV radiation could be immunosuppressive (Fisher and Kripke 1978). It was later observed that this inhibited anti-tumor immunity could be transferred to recipient mice with splenic T lymphocytes from such UV-irradiated donor mice, and thus, the dependence of the development of skin cancer on UV-induced defective T cell-mediated immunity was revealed (Fisher and Kripke 1982; Ullrich and Kripke 1984).

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