Predictive Modeling of Gene Expression Data

Authored by: Alexander Hapfelmeier , Waheed Babatunde Yahya , Robert Rosenberg , Kurt Ulm

Handbook of Statistics in Clinical Oncology

Print publication date:  March  2012
Online publication date:  March  2012

Print ISBN: 9781439862001
eBook ISBN: 9781439862018
Adobe ISBN:

10.1201/b11800-31

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Abstract

The treatment of cancer has changed over the past centuries, moving away from the administration of broadly acting cytotoxic drugs toward the use of more specific therapies (van’t Veer and Bernards [33]). There is a shift from a “one-size” or “one-dose-fits-all” approach to a more personalized medicine. The idea behind this is to give the right dose of the right drug for the right indication for the right patient in the right time. Hamburg and Collins [12] called this approach a path to personalized medicine and described the need for the Food and Drug Administration (FDA) and National Institutes of Health (NIH) to support its growth. They gave three examples of FDA-approved drugs and diagnostics.

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