Biosensors in Bioprocess Monitoring and Control

Current Trends and Future Prospects

Authored by: Chris E. French , Chris Gwenin

Fermentation Microbiology and Biotechnology

Print publication date:  December  2011
Online publication date:  December  2011

Print ISBN: 9781439855799
eBook ISBN: 9781439855812
Adobe ISBN:


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The application of sensors to bioprocess monitoring of fermentation parameters such as pH, temperature, and dissolved oxygen, once a major challenge, is now a standard procedure irrespective of the scale of fermentation because the enabling technologies are well established; for further details on control of fermentation processes, see chapter 16 and 17 in this volume. Offline monitoring of other parameters, such as substrate utilization and product formation, is also important and is achieved using enzymic assays and analytical techniques such as HPLC, GCMS, or ELISA, but this involves inevitable delays, with implications for process control and management. In this chapter, we examine the scientific basis underlying biosensor design and control and explore the potential benefits of their applications.

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