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Common Protocols on Membrane Lipid Analysis and Lipidomics

Authored by: Arun Kumar Das

Handbook of Molecular and Cellular Methods in Biology and Medicine

Print publication date:  December  2011
Online publication date:  April  2016

Print ISBN: 9781420069389
eBook ISBN: 9781439881958
Adobe ISBN:

10.1201/b11351-34

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Abstract

Lipids, defined as fat soluble (lipophilic) molecules, are structurally the derivatives of fatty acid in a majority of cases, with glycerol as glycerides or phosphoglycerides and other molecules related biosynthetically or functionally to these compounds. Membrane lipids of mammalian cells are largely composed of glycerol neutral and phospholipids. They are the integral part of membrane structure, function, and composition. For a long time, research in this area was mainly limited to the classical methods of lipid analysis, such as the classification, quantitation, and composition of different lipid molecules, until the discoveries of lipids playing vital roles as biological messengers, cell membrane protectors, membrane bound protein anchors, regulators of actions of hormones and pheromones, and signal transducers in various cellular phenomenon were made. 1 4 A number of genetic diseases have been identified to be due to abnormalities of lipid storage or aberrations of lipid functions. 5 8

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