Proteomics Data Collection and Analysis

Authored by: Evelyn H. Kim , David E. Misek , Margaret V. Westfall

Handbook of Molecular and Cellular Methods in Biology and Medicine

Print publication date:  December  2011
Online publication date:  April  2016

Print ISBN: 9781420069389
eBook ISBN: 9781439881958
Adobe ISBN:

10.1201/b11351-32

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Abstract

The underlying structural and functional properties of each organ are determined, in part, by the proteins expressed within the cells of each organ system. Gene expression profiling of both human and animal tissues has increased exponentially, following the completion of genome sequencing of humans and other animal models. Gene expression often reflects protein expression and these studies have not only greatly improved our understanding of protein expression in cells, but have also improved our understanding of many disease processes. 1 However, there are tissues/organs and/or disease states in which messenger RNA (mRNA) levels may not necessarily reflect protein expression. 2 4 Thus, in-depth detection and analysis of protein expression is needed to better understand tissue/organ structure and function.

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