Photodynamic Therapy/Diagnostics: Principles, Practice, and Advances

Authored by: Brian C. Wilson

Handbook of Photonics for Biomedical Science

Print publication date:  May  2010
Online publication date:  May  2010

Print ISBN: 9781439806289
eBook ISBN: 9781439806296
Adobe ISBN:

10.1201/9781439806296-c25

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Abstract

The term photodynamic therapy (PDT) as applied to biomedical science and, more particularly, to clinical medicine is generally defined as the use of a compound or drug (photosensitizer) that has no or minimal effect alone but which, when activated by light, generates one or more reactive chemical species that are able to modify or kill cells and tissues. As historically defined, the PDT reaction should be mediated by oxygen, through the generation of reactive oxygen, most commonly singlet-state oxygen (1O2). However, there are photosensitizers under development that may use oxygen-independent photophysical pathways and we will include them as de facto photodynamic agents also.

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