FDTD Simulation of Light Interaction with Cells for Diagnostics and Imaging in Nanobiophotonics

Authored by: Stoyan Tanev , Wenbo Sun , James Pond , Valery V. Tuchin

Handbook of Photonics for Biomedical Science

Print publication date:  May  2010
Online publication date:  May  2010

Print ISBN: 9781439806289
eBook ISBN: 9781439806296
Adobe ISBN:

10.1201/9781439806296-c1

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Abstract

This chapter describes the mathematical formulation of the Finite-Difference Time-Domain (FDTD) approach and provides examples of its applications to biomedical photonics problems. The applications focus on two different configurations – light scattering from single biological cells and Optical Phase Contrast Microscope (OPCM) imaging of cells containing gold nanoparticles. The validation of the FDTD approach for the simulation of OPCM imaging opens a new application area with a significant research potential – the design and modeling of advanced nanobioimaging instrumentation.

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