Cell Oxidative Stress: Risk of Metal Nanoparticles

Authored by: Marija Poljak-Blazi , Morana Jaganjac , Neven Zarkovic

Handbook of Nanophysics

Print publication date:  September  2010
Online publication date:  September  2010

Print ISBN: 9781420075465
eBook ISBN: 9781420075496
Adobe ISBN:

10.1201/9781420075496-19

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Abstract

Nanoparticles are of great scientific interest as a bridge between bulk materials and sophisticated constructs that can be useful in various fields of material and life sciences. A bulk material should have constant physical properties regardless of its size, but at the nanoscale this is often not the case. The properties of materials change as their size approaches the nanoscale and as the percentage of atoms at the surface of a material becomes significant. Interesting and sometimes even unexpected properties of nanoparticles are partly due to the aspects of the surface of the material dominating the properties in lieu of the bulk properties. In contrast to many efforts aimed at exploiting the desirable properties of nanoparticles for medicine, there are limited attempts at evaluating the potentially undesirable effects of these particles when administered for medical purposes. Nanoparticles are likely to be the cornerstones of innovative nanomedical devices to be used for drug discovery and delivery, discovery of biomarkers, and molecular diagnostics.

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