Metabolic Flux Analysis in Corynebacterium glutamicum

Authored by: C. Wittmann , A.A. De Graaf

Handbook of Corynebacterium glutamicum

Print publication date:  March  2005
Online publication date:  March  2005

Print ISBN: 9780849318214
eBook ISBN: 9781420039696
Adobe ISBN:


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Initiated by the pioneering discovery of the glutamate-producing Corynebacterium glutamicum [20], extensive biochemical and genetical analysis of the metabolic network of this microorganism has been carried out [11,21,39]. This provided detailed knowledge on its enzymes and pathways and was therefore very useful for the optimization of strains and production processes. In recent years, novel approaches were developed that allow the in vivo quantification of fluxes in the metabolism of C. glutamicum. These approaches revealed fascinating insights into metabolic properties of C. glutamicum otherwise not accessible. In addition, they offered new possibilities as a rational basis for targeted strain improvement. The present chapter gives an overview of metabolic flux quantifications of C. glutamicum, whereby, with respect to metabolic fluxes, C. glutamicum is probably the most extensively studied organism so far.

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