Central Metabolism: Tricarboxylic Acid Cycle and Anaplerotic Reactions

Authored by: B. Eikmanns

Handbook of Corynebacterium glutamicum

Print publication date:  March  2005
Online publication date:  March  2005

Print ISBN: 9780849318214
eBook ISBN: 9781420039696
Adobe ISBN:


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Corynebacterium glutamicum is able to grow aerobically on a variety of carbohydrates, alcohols, and organic acids as single or combined sources of carbon and energy [53]. Invariably, independent of the carbon and energy sources used, the tricarboxylic acid (TCA) cycle (Figure 11.1), or at least parts of it, must be active [52]. One reason is that the TCA cycle serves catabolic and anabolic purposes as well [16,32]. On the one hand it is responsible for the complete oxidation of acetylCoA derived from the different substrates, it generates ATP (or GTP), and it provides reducing equivalents to membrane-bound respiratory systems. On the other hand it provides precursor metabolites for biosynthetic processes such as 2-oxoglutarate and oxaloacetate. During growth on substrates entering the central metabolism at the level of acetyl-CoA, e.g., acetate, fatty acids, or ethanol, the glyoxylate cycle is active (Figure 11.1) [50]. This bypass of the TCA cycle avoids the oxidative decarboxylation steps of isocitrate dehydrogenase (ICD) and the 2-oxoglutarate dehydrogenase complex (OGDHC) and finally leads to the net formation of one molecule of malate from two molecules of acetyl-CoA.

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