Abstract

There are three basic considerations when choosing a radionuclide for targeted radiotherapy:

Physical properties of the radionuclide (i.e. type, yield and energy of emissions, and physical half-life)

Chemical properties in relation to: conjugation and binding stability; targeting molecule; and accumulation, retention and clearance profiles for the tissues of interest

Production methods in relation to radioactivity levels and chemical and radiochemical purity suitable for clinical application and specific activity requirements when, for example, conjugated to a receptor ligand type molecule (Zweit 1996)