Radionuclide Selection for Unsealed Source Therapy

Authored by: Maggie Flower , Jamal Zweit , Mark Atthey

Handbook of Radiotherapy Physics

Print publication date:  June  2007
Online publication date:  June  2007

Print ISBN: 9780750308601
eBook ISBN: 9781420012026
Adobe ISBN:

10.1201/9781420012026.ch57

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Abstract

There are three basic considerations when choosing a radionuclide for targeted radiotherapy:

Physical properties of the radionuclide (i.e. type, yield and energy of emissions, and physical half-life)

Chemical properties in relation to: conjugation and binding stability; targeting molecule; and accumulation, retention and clearance profiles for the tissues of interest

Production methods in relation to radioactivity levels and chemical and radiochemical purity suitable for clinical application and specific activity requirements when, for example, conjugated to a receptor ligand type molecule (Zweit 1996)

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