Adaptive Design Methods in Clinical Trials

Authored by: Shein-Chung Chow , Annpey Pong

Encyclopedia of Biopharmaceutical Statistics

Print publication date:  August  2018
Online publication date:  August  2018

Print ISBN: 9781498733953
eBook ISBN: 9781351110273
Adobe ISBN:

10.1201/9781351110273-140000320

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Abstract

The aim of this entry is not only to provide a comprehensive summarization of the issues that are commonly encountered when applying/implementing the adaptive design methods in clinical research but also to include recent development such as the role of the independent data safety monitoring board and sample size estimation/allocation, justification, and adjustment when implementing a much more complicated adaptive design in clinical trials.

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