MCP-Mod: Dose–Response Testing and Estimation

Authored by: Björn Bornkamp , Naitee Ting

Encyclopedia of Biopharmaceutical Statistics

Print publication date:  August  2018
Online publication date:  August  2018

Print ISBN: 9781498733953
eBook ISBN: 9781351110273
Adobe ISBN:

10.1201/9781351110273-140000065

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Abstract

Multiple comparison procedures and modeling (MCP-Mod) is a method for dose–response testing and dose–response estimation under model uncertainty. The dose–response modeling is based on a set of candidate dose–response shapes that is predefined at the design stage of the trial. The methodology consists of two main steps. The first step is a statistical test for a dose–response signal, assessing whether there is any effect of the test doses over placebo (the MCP step). This is performed by utilizing a multiple contrast test procedure, where each of the candidate shape is represented by a contrast. In the second step, the dose–response curve is estimated based on model selection or model averaging techniques, utilizing the predefined candidate dose–response models.

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