Propensity Score: Methodology and Application to Clinical Studies

Authored by: Lilly Q. Yue , Heng Li

Encyclopedia of Biopharmaceutical Statistics

Print publication date:  August  2018
Online publication date:  August  2018

Print ISBN: 9781498733953
eBook ISBN: 9781351110273
Adobe ISBN:


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Formulated by Rosenbaum and Rubin, the propensity score methodology is a versatile statistical technique used mainly in observational (non-randomized) studies for improving treatment comparison by adjusting for up to a relatively large number of potentially confounding covariates in estimating the effect of treatments on outcomes. Since its formulation, the methodology has been widely used in areas such as epidemiological and social science studies. There has been an increased interest in applying this methodology to non-randomized clinical studies, including those designed to support regulatory applications for marketing medical products. This entry gives a brief overview of propensity score methods and discusses important things to consider in the application of these methods in clinical studies, especially those submitted for regulatory review.

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