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Multiple-Stage Designs: Phase II Cancer Trials
- Introduction
- Hypothesis Testing
- Single-Stage Design
- Multi-Stage Design
- Binomial Response
- Flexible Designs
- Remark.
- Designs that Jointly Evaluate Efficacy and Toxicity
- Randomized Discontinuation Design
- Trinomial Response
- Conclusion
- References
Abstract
This entry provides a review of several widely used multi-stage designs, along with some recently proposed modifications, improvements, and extensions. Binomial and trinomial response models are considered in detail, and some additional multi-stage designs are discussed.
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