Cancer Chemotherapy: Maximum Tolerable Dose

Authored by: Jen-pei Liu

Encyclopedia of Biopharmaceutical Statistics

Print publication date:  August  2018
Online publication date:  August  2018

Print ISBN: 9781498733953
eBook ISBN: 9781351110273
Adobe ISBN:

10.1201/9781351110273-130001120

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Abstract

Statistically, the maximum tolerable dose is defined as some percentile of a tolerance distribution or dose-response curve in terms of the presence or absence of dose-limiting toxicity. This entry details how MTD can be determined in accordance with patient safety.

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