Hypotheses and False Positive Rate in Active Control Non-Inferiority Trials

Authored by: Gang Chen , George Y. H. Chi , Yong-Cheng Wang

Encyclopedia of Biopharmaceutical Statistics

Print publication date:  August  2018
Online publication date:  August  2018

Print ISBN: 9781498733953
eBook ISBN: 9781351110273
Adobe ISBN:

10.1201/9781351110273-130001096

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Abstract

Hypotheses and False Positive Rate in Active Control Non-Inferiority Trials. The hypotheses in non-inferiority trials involve two unknown parameters. Statistical inferences on non-inferiority hypotheses, ideally, should be based on randomized data collected in the current trial. This entry reviews some of the ethical issues in active control non-inferiority trials and presents statistical models for performing this type of trial.

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