Covariate-Adjusted Adaptive Dose-Finding: Early Phase Clinical Trials

Authored by: Peter F. Thall , Hoang Q. Nguyen

Encyclopedia of Biopharmaceutical Statistics

Print publication date:  August  2018
Online publication date:  August  2018

Print ISBN: 9781498733953
eBook ISBN: 9781351110273
Adobe ISBN:


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Most methods for sequentially adaptive dose-finding in phase I clinical trials characterize outcome as an indicator yt of toxicity and assume that patients are homogeneous. This entry reviews a new method which requires an informative prior on covariate effect parameters, obtained from historical data.

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