Sorry, you do not have access to this eBook
A subscription is required to access the full text content of this book.
Metrics
Views
232
In This Chapter
-
Clinical Trial Simulations: Earlier Development Phases
- Introduction
- Overview of Dose-Escalation Trial
- Objectives of a Phase I Clinical Trial
- Population for Treatment
- Dose-Limited Toxicity and Maximum Tolerated Dose
- Dose-Level Selection
- Sample Size Per Dose Level
- Traditional Dose-Escalation Design
- Two-stage Dose-Escalation Design
- Evaluation of Dose-Escalation Algorithms
- Simulation Example using TER and TSER
- Continual Reassessment Method
- Assignment of Next Patient
- Simulation Example using CRM
- Conclusions
- References
Abstract
This entry discusses the simulation in early phases of clinical trials, specifically through oncology dose-escalation trials to discuss some theoretical and practical issues in trial simulations.
Other ways to access this content:
Email to request access
Purchase this book
Related chapters
Search for more...
© Informa UK Limited, an Informa Group Company
Home | About RHO | Collections
| Free trial
| How to buy
| Promotions
| Contact us | Help & FAQs
Librarian resources
| Privacy policy
| Cookies
| Terms & conditions
