Center Weighting: Multicenter Trials

Authored by: Paul Gallo

Encyclopedia of Biopharmaceutical Statistics

Print publication date:  August  2018
Online publication date:  August  2018

Print ISBN: 9781498733953
eBook ISBN: 9781351110273
Adobe ISBN:

10.1201/9781351110273-130001040

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Abstract

The primary motivation for using multiple centers is to enable enrollment of a sufficient number of clinical trial patients to investigate a hypothesis in a timely manner. This entry reviews the advantages of center weighting in multicenter trials, looks at the construction of composite centers, and discusses the regulatory guidelines of such trials.

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