Treatment planning part III: Dosimetric considerations in radioembolization with glass and resin microspheres

Authored by: Alexander S. Pasciak , Austin C. Bourgeois , Yong C. Bradley

Handbook of Radioembolization

Print publication date:  October  2016
Online publication date:  November  2016

Print ISBN: 9781498742016
eBook ISBN: 9781315369150
Adobe ISBN:

10.1201/9781315369150-5

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Abstract

5.1 Background

87

5.2 Absorbed dose, effective dose, and dosage

88

5.2.1 Absorbed dose

89

5.2.2 Dosage

89

5.2.3 Effective dose

89

5.3 One microsphere or millions of microspheres?

89

5.4 Distribution in tissue

91

5.5 Calculating the absorbed dose

93

5.6 Tumor and normal liver endpoints

94

5.6.1 Normal liver endpoints

94

5.6.2 Tumor endpoints

95

5.7 Tumor-to-normal uptake ratio

95

5.7.1 Using MAA as an estimation tool

96

5.7.2 Other tools?

97

5.8 Treatment planning strategies

97

5.8.1 The empiric model for resin microsphere treatment planning

97

5.8.2 The BSA model for resin microsphere treatment planning

98

5.8.3 Glass microsphere treatment planning

98

5.8.4 The partition model

99

5.8.5 Comparing treatment planning models

99

5.9 Contouring liver and tumor volumes

100

5.9.1 Automatic and semiautomatic segmentation

101

5.9.2 Manual segmentation

101

5.10 Treatment planning calculations

103

5.10.1 Lobar therapy

103

5.10.2 Selective therapy

106

5.11 Conclusions

109

References

109

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