Introduction to hepatic radioembolization

Authored by: Andor F. Van Den Hoven , Daniel Y. Sze , Marnix G.E.H. Lam

Handbook of Radioembolization

Print publication date:  October  2016
Online publication date:  November  2016

Print ISBN: 9781498742016
eBook ISBN: 9781315369150
Adobe ISBN:

10.1201/9781315369150-1

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Abstract

1.1 General introduction

3

1.1.1 What is radioembolization?

3

1.1.2 A brief history of radioembolization

4

1.1.3 Indications for radioembolization

6

1.1.4 Comparison of radioembolization and external beam radiation therapy principles

7

1.2 Types of microspheres and radionuclides used

8

1.2.1 Yttrium-90 microspheres

8

1.2.2 Holmium-166 microspheres

10

1.3 Pretreatment workup

11

1.3.1 Laboratory and clinical investigations

11

1.3.2 Pretreatment imaging: liver CT/MRI and 18F-FDG-PET

11

1.3.3 Assessing the individual hepatic arterial anatomy

12

1.3.4 Preparatory angiography and intraprocedural imaging

13

1.3.5 Imaging of the scout dose distribution

15

1.3.6 Pretreatment activity calculations

16

1.4 Treatment

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1.4.1 Medication and periprocedural care

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1.4.2 Treatment technique

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1.4.3 Catheter types and particle-fluid dynamics

18

1.4.4 Imaging of the therapeutic microsphere distribution

18

1.4.5 Dose–response relationship

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1.5 Treatment-related laboratory and clinical toxicity

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1.5.1 Complaints during treatment

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1.5.2 Laboratory toxicity

19

1.6 Tumor response assessment

21

1.6.1 Anatomical tumor response assessment

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1.6.2 Functional tumor response assessment

22

1.7 Conclusion

23

References

23

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