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Authored by: Kimball Nill

Glossary of Biotechnology and Agrobiotechnology Terms

Print publication date:  July  2016
Online publication date:  September  2016

Print ISBN: 9781498758208
eBook ISBN: 9781315367811
Adobe ISBN:

10.1201/9781315367811-15

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Abstract

Refers to a line of laboratory mice (genotype Foxn1 nu) that are descended from a mouse in which many years ago occurred a spontaneous mutation which results in (descendants) that:

Do not develop any thymus-derived T cells.

Do not develop hair follicles in their epithelium (skin).

Because this line of laboratory mice will therefore “accept” (i.e., immune system will not attack) a wide variety of transplants (e.g., tumors, etc. from other animals), it is a common research test subject for researchers who want to test the impact of a new pharmaceutical compound on—tumor, and so on. Another aspect making it a commonly chosen test subject is the fact that scientists do not have to shave the mouse in order to measure size of the subcutaneous inserted tumors. See also Genotype, Mutation, Thymus, T cells, Tumor, Epithelium.

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