3D Dosimetry in Synchrotron Radiation Therapy Techniques

Authored by: Elke Bräuer-Krisch

Clinical 3D Dosimetry in Modern Radiation Therapy

Print publication date:  October  2017
Online publication date:  October  2017

Print ISBN: 9781482252217
eBook ISBN: 9781315118826
Adobe ISBN:

10.1201/9781315118826-25

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Abstract

Stereotactic synchrotron radiotherapy (SSRT) and microbeam radiation therapy (MRT) are novel approaches in radiation therapy to treat brain tumors and potentially other tumors using synchrotron radiation (Bräuer-Krisch et al., 2010a; Balosso et al., 2014). SSRT is based on a local drug uptake of high-Z elements in tumors followed by stereotactic irradiation with 80-keV photons to enhance the dose deposition only within the tumor (Biston et al., 2004; Adam et al., 2006). Phase I SSRT clinical trials started in 2014 combining conventional radiotherapy (RT) with one fraction of the treatment delivered at the European Synchrotron Radiation Facility (ESRF) (Balosso et al., 2014). Medical physics aspects such as the integration of the iodine concentration in the treatment planning system (TPS) to accurately determine the dose in the tumor were successfully benchmarked. Also, a dosimetry protocol for absolute dose measurements was established (Prezado et al., 2011; Vautrin, 2011; Obeid et al., 2014). For MRT, the medical physics aspects are particularly challenging due to the very small-field sizes. For instance, in case of plane parallel beams, field sizes having a full width at half maximum (FWHM) of 25 μm by several centimeters in height, down to 50 μm × 50 μm spot sizes for pencil beams are used. Potential dosimeters for MRT were investigated over the last 15 years (Bräuer-Krisch et al., 2010b), with a more recent review article (Bräuer-Krisch et al., 2015) summarizing the most important developments in high-resolution dosimetry for MRT.

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