Dosimetry of Small Animal Precision Irradiators

Authored by: Frank Verhaegen , Dietmar Georg

Clinical 3D Dosimetry in Modern Radiation Therapy

Print publication date:  October  2017
Online publication date:  October  2017

Print ISBN: 9781482252217
eBook ISBN: 9781315118826
Adobe ISBN:

10.1201/9781315118826-24

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Abstract

A modern trend in radiation biology preclinical research is to mimic, from a technological point of view, the radiation conditions of human radiotherapy as closely as possible. This has led, in the last decade, to a range of commercial and in-house-made irradiators, which often come equipped with various imaging devices to allow image-guided irradiation (Verhaegen et al., 2011; Tillner et al., 2014, 2016). Several of these devices include a gantry that allows a kilovolt (kV) x-ray radiation source to irradiate target structures from different angles, with very small beams (down to 0.5 mm diameter). This novel equipment has enabled high-precision radiation experiments which may lead to new fundamental insights or allow improved translational studies. The advanced radiation research platforms offer opportunities to precisely target tumors, or substructures therein, and can also be used for innovative normal tissue-response studies. The availability of these new platforms is expected to lead to major advances in radiation oncology, in combination with other anticancer agents (Butterworth et al., 2015).

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