Mitochondrial Dysfunction in Multiple Sclerosis

Authored by: Angela Dziedzic , Elzbieta Miller , Joanna Saluk-Bijak , Michał Bijak

Handbook of Mitochondrial Dysfunction

Print publication date:  June  2019
Online publication date:  May  2019

Print ISBN: 9781138336087
eBook ISBN: 9780429443336
Adobe ISBN:

10.1201/9780429443336-8

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Abstract

Oxidative stress and mitochondrial dysfunction have been implicated in the pathogenesis of neurodegenerative diseases, including multiple sclerosis (MS). MS has been considered as a chronic, inflammatory disorder of the central nervous system in which ensuing demyelination and axonal damage that result in physical disability affecting over 2 million people worldwide. Mitochondrial dysfunction is distinguished by the overproduction of reactive oxygen species, which can induce the mitochondrial DNA mutations, disrupt the calcium ions homeostasis, impair mitochondrial respiratory chain and alter membrane permeability. Neurons are highly dependent on oxidative energy metabolism. Extreme production of free radicals leads to axonal injury, leukocyte migration and oligodendrocyte damage can be observed in MS patients. Importantly, all these changes are implicated in the development of mediating and/or amplifying neuronal dysfunction and triggering neurodegeneration. Therefore, more insight into the cause and consequences of impaired mitochondrial function provide a foundation for mitochondrial-targeted medicine to combat progressive MS.

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