Mitochondrial Dysfunction in the Pathophysiology of Alzheimer’s Disease

Authored by: Isaac G. Onyango

Handbook of Mitochondrial Dysfunction

Print publication date:  June  2019
Online publication date:  May  2019

Print ISBN: 9781138336087
eBook ISBN: 9780429443336
Adobe ISBN:

10.1201/9780429443336-7

 Download Chapter

 

Abstract

Mitochondria are responsible for the majority of energy production in the brain, modulate Ca+2 signaling and control initiation of cell death. Because of their extensive use of oxygen and lack of protective histone proteins, mitochondria are particularly vulnerable to oxidative stress (ROS)-induced damage to their genome (mtDNA), respiratory chain proteins and ROS repair enzymes. Maintenance of mitochondrial mass, mitochondrial biogenesis (mitobiogenesis), particularly in high-energy utilizing brain, occurs through complex signaling pathways involving the upstream “master regulator” PGC-1α which is transcriptionally and post-translationally regulated.

 Cite
Search for more...
Back to top

Use of cookies on this website

We are using cookies to provide statistics that help us give you the best experience of our site. You can find out more in our Privacy Policy. By continuing to use the site you are agreeing to our use of cookies.