Mitochondrial Dysfunction in the Pathophysiology of Alzheimer’s Disease

Authored by: Isaac G. Onyango

Handbook of Mitochondrial Dysfunction

Print publication date:  June  2019
Online publication date:  May  2019

Print ISBN: 9781138336087
eBook ISBN: 9780429443336
Adobe ISBN:


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Mitochondria are responsible for the majority of energy production in the brain, modulate Ca+2 signaling and control initiation of cell death. Because of their extensive use of oxygen and lack of protective histone proteins, mitochondria are particularly vulnerable to oxidative stress (ROS)-induced damage to their genome (mtDNA), respiratory chain proteins and ROS repair enzymes. Maintenance of mitochondrial mass, mitochondrial biogenesis (mitobiogenesis), particularly in high-energy utilizing brain, occurs through complex signaling pathways involving the upstream “master regulator” PGC-1α which is transcriptionally and post-translationally regulated.

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