Organophosphorus Compound-Induced Mitochondrial Disruption

Authored by: Alan J. Hargreaves

Handbook of Mitochondrial Dysfunction

Print publication date:  June  2019
Online publication date:  May  2019

Print ISBN: 9781138336087
eBook ISBN: 9780429443336
Adobe ISBN:

10.1201/9780429443336-36

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Abstract

Organophosphorus compounds (OPs) are widely used in a range of agricultural, industrial and domestic applications. There is concern over their ability to induce acute and delayed neurotoxicity in non-target organisms including humans, by inhibition of acetylcholinesterase or disruption of other cellular activities in a variety of ways, respectively. This chapter discusses the potential importance of mitochondrial disruption as a key event in OP-induced neurotoxicity.

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