Mitochondrial Stress and Cellular Senescence

Authored by: Irene L. Tan , Michael C. Velarde

Handbook of Mitochondrial Dysfunction

Print publication date:  June  2019
Online publication date:  May  2019

Print ISBN: 9781138336087
eBook ISBN: 9780429443336
Adobe ISBN:

10.1201/9780429443336-29

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Abstract

Cellular senescence is the permanent growth arrest of cells developed after undergoing several rounds of cell division. It may also be induced by a variety of stressors, such as DNA damage, oxidative stress, and mitochondrial stress. Mitochondrial stress is thought to induce cellular senescence through mitochondrial-generated reactive oxygen species (ROS) and other signaling pathways. Conversely, cellular senescence also leads to impaired mitochondrial function. This chapter introduces the concept of cellular senescence and its relationship with mitochondrial stress. Mitochondrial dysfunction-associated senescence (MiDAS) will be compared with senescent cells induced through other stress factors in terms of phenotypic features, signaling pathways, and protein secretion. Mitochondrial damage in senescent cells, referred to as Senescence-associated mitochondrial dysfunction (SAMD), will also be discussed.

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