Pathophysiology and Biomarkers of Mitochondrial Dysfunction Induced by Heavy Exercise

Authored by: Sergej M. Ostojic

Handbook of Mitochondrial Dysfunction

Print publication date:  June  2019
Online publication date:  May  2019

Print ISBN: 9781138336087
eBook ISBN: 9780429443336
Adobe ISBN:

10.1201/9780429443336-27

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Abstract

Exercise-induced mitochondrial dysfunction (EIMD) in particular the heavy exercise is a subclinical syndrome that includes irreversible changes in mitochondrial structure and function. Primarily caused by prolonged and repetitive exhaustive exercise; this complex and vexed condition have been suggested as a proxy for many deleterious health consequences of exercise, including chronic fatigue syndrome, heart abnormalities, immune disorders, muscle injuries and brain dysfunction. Biochemical perturbations, heat elevation and mechanical disruption generated by exercise are possible triggers for mitochondrial dysfunction, with the skeletal muscle and myocardial mitochondria particularly susceptible to damage. This chapter begins with a description of different pathophysiological features of EIMD, and then covers altering factors that mediate EIMD in human and animal models. Finally, possible biomarkers of EIMD in clinical and experimental medicine have been presented.

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