The Effects of Resveratrol on the Brain Mitochondria

Authored by: Marcos Roberto de Oliveira

Handbook of Mitochondrial Dysfunction

Print publication date:  June  2019
Online publication date:  May  2019

Print ISBN: 9781138336087
eBook ISBN: 9780429443336
Adobe ISBN:

10.1201/9780429443336-26

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Abstract

Resveratrol (RES; also called 3,4สน,5-trihydroxystilbene; C14H12O3) is a phytoalexin found mainly in the grapes and in red wine. RES exhibits antioxidant, anti-apoptotic, and anti-inflammatory actions in several experimental models. Moreover, RES triggers apoptosis in tumor cells. The effects induced by RES have been seen in different mammalian tissues; however, the effects of RES on the brain have attracted the attention of researchers worldwide due to the brain particularities, such as high oxygen (O2) consumption, low levels of non-enzymatic and enzymatic antioxidant defenses, and high amounts of peroxidisable lipids, as well as a high content of transition metals.

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