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Handbook of Mitochondrial Dysfunction

Edited by: Shamim I. Ahmad

Print publication date:  June  2019
Online publication date:  May  2019

Print ISBN: 9781138336087
eBook ISBN: 9780429443336
Adobe ISBN:

10.1201/9780429443336
 Cite  Marc Record

Book description

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.

Key Features

  • Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction.
  • Includes summary of both causes and effects of these diseases.
  • Discusses current and potential future therapies for mitochondrial dysfunction diseases
  • Explores a wide variety of diseases caused by dysfunctional mitochondria.

Table of contents

Prelims Download PDF
Chapter  1:  Mitochondrial Structure and Function Download PDF
Chapter  2:  Structure, Function and Evolutionary Aspects of Mitochondria Download PDF
Chapter  3:  Mitochondrial Genome Damage, Dysfunction and Repair Download PDF
Chapter  4:  Instability of Human Mitochondrial DNA, Nuclear Genes and Diseases Download PDF
Chapter  5:  Kearns-Sayre Syndrome Download PDF
Chapter  6:  Mitochondrial Dysfunction and Barth Syndrome Download PDF
Chapter  7:  Mitochondrial Dysfunction in the Pathophysiology of Alzheimer’s Disease Download PDF
Chapter  8:  Mitochondrial Dysfunction in Multiple Sclerosis Download PDF
Chapter  9:  Mitochondrial Dysfunction in Chronic Kidney Disease Download PDF
Chapter  10:  Mitochondrial Dysfunction in Breast Cancer Download PDF
Chapter  11:  Mitochondrial Dysfunction and DNA Methylation in Atherosclerosis Download PDF
Chapter  12:  Mitochondrial Dysfunction and Heart Diseases Download PDF
Chapter  13:  The Role of Mitochondrial Dysfunction in Mitophagy and Apoptosis and Its Relevance to Cancer Download PDF
Chapter  14:  Mitochondrial Dysfunction Linking Obesity and Asthma Download PDF
Chapter  15:  Mitochondrial Dysfunction and Hearing Loss Download PDF
Chapter  16:  Superoxide Dismutase, Mitochondrial Dysfunction, and Neurodegenerative Diseases Download PDF
Chapter  17:  Role of Post-Translational Modifications of Mitochondrial Complex I in Mitochondrial Dysfunction and Human Brain Pathologies Download PDF
Chapter  18:  Heme Oxygenase-1 in Kidney Health and Disease Download PDF
Chapter  19:  Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury Download PDF
Chapter  20:  Mitochondrial Dysfunction in Diabetes Download PDF
Chapter  21:  Clinical Manifestation of Mitochondrial Disorders in Childhood Download PDF
Chapter  22:  Mitochondrial Dysfunction and Epilepsies Download PDF
Chapter  23:  Mitochondrial Dysfunction and Allergic Disease Download PDF
Chapter  24:  Role of Carnosic Acid in Protection of Brain Mitochondria Download PDF
Chapter  25:  Mitochondrial Dysfunction and Its Impact on Oxidative Capacity of Muscle Download PDF
Chapter  26:  The Effects of Resveratrol on the Brain Mitochondria Download PDF
Chapter  27:  Pathophysiology and Biomarkers of Mitochondrial Dysfunction Induced by Heavy Exercise Download PDF
Chapter  28:  Mitochondrial Pathologies and Their Neuromuscular Manifestations Download PDF
Chapter  29:  Mitochondrial Stress and Cellular Senescence Download PDF
Chapter  30:  Role of Mitochondrial Dysfunction in Human Obesity Download PDF
Chapter  31:  Roles of Melatonin in Maintaining Mitochondrial Welfare Download PDF
Chapter  32:  Mitochondrial Dysfunction Affecting the Peripheral Nervous System in Diabetic Neuropathy and Avenues for Therapy Download PDF
Chapter  33:  Mitochondrial Dysfunction and Oxidative Stress in the Pathogenesis of Metabolic Syndrome Download PDF
Chapter  34:  Regulation of Antiviral Immunity by Mitochondrial Dynamics Download PDF
Chapter  35:  Mitochondrial Dysfunction, Immune Systems, Their Diseases, and Possible Treatments Download PDF
Chapter  36:  Organophosphorus Compound-Induced Mitochondrial Disruption Download PDF
Chapter  37:  Mitochondrial Dysfunction in Friedreich Ataxia Download PDF
Index Download PDF
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